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of elderly persons tested in this way contained a signi cant proportion in which cerebral blood ow was equivalent to that in young control subjects In fact, in a group of 72-year-old men rigorously selected on the basis of freedom from disease, Sokoloff demonstrated that cerebral blood ow and oxygen consumption did not differ from those of normal men 22 years of age Cerebral glucose metabolism was reduced in all the elderly subjects, however With advancing age there is a general tendency for the electroencephalogram (EEG) to show a slowing of the alpha rhythm, an increase in beta activity, a decline in the percentage of slowwave sleep, and an increasing intrusion of theta rhythms, particularly over the temporal lobes There are large individual differences, however With respect to the neurotransmitters, it is generally agreed that the concentrations of acetylcholine, norepinephrine, and dopamine decline in the course of normal aging Also, the concentration of gamma-aminobutyric acid (GABA) has been shown to decline with age, particularly in the frontal cortex (Spokes et al) Analyses of postmortem human and animal brains have failed to demonstrate a decline with age in the concentration of serotonin or its metabolites (McEntee and Crook) Accurate assessment of other neurotransmitters has been more dif cult because of their marked lability in postmortem material Data from experiments in rats suggest that the glutamate content of the brain and the number of Nmethyl-D-aspartate (NMDA) receptors diminish with age, but the functional signi cance of this nding is unclear Unlike the case in Alzheimer disease, normal aging is associated with only slight and inconsistent abnormalities of cholinergic innervation of the hippocampus and cortex This is true also of the acetylcholine content and the activity of choline acetyltransferase (the synthesizing enzyme of acetylcholine) in these regions and the number of cholinergic neurons in the nucleus basalis of Meynert (substantia innominata) and other nuclei of the basal forebrain (Decker) Again, the signi cance of these changes is dif cult to judge They probably re ect the depletion of cells that occurs with aging The topics of cholinergic and glutamatergic function in the aging brain have been critically reviewed by McEntee and Crook.

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<%@ Page Language="C#" AutoEventWireup="true" Inherits="CalAppt" %> CodeFile="CalMindaspxcs"

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With advancing age, skeletal muscles lose cells ( bers) and undergo a gradual reduction in their weight more or less parallel to that of the brain Atrophy of muscles and diminution in peak power and endurance are clinical expressions of these changes Many processes contribute to this age-dependent loss of lean muscle mass, described as sarcopenia These include decreased physical activity; diminished appetite associated with loss of smell and elevated levels of cholcystokinin, a satiety hormone; other endocrine changes such as diminished levels of growth hormone and androgens; and (as in the brain) the accumulation of subcellular defects such as nuclear and mitochondrial DNA mutations alluded to earlier Moreover, with aging, the slow loss of motor neurons contributes to a component of denervation atrophy Our own observations of neuropathologic material indicate that the wasting involves several processes, some principally myopathic and others relating to disuse or denervation, from loss of motor neurons In this material, denervation atrophy of the gastrocnemius muscles was found in 80 percent of individuals over 70 years of age The lost muscle bers are gradually replaced by endomysial connective tissue and fat cells The surviving bers are generally thinner than normal (pos-

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<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 10 Transitional//EN" "http://wwww3org/TR/xhtml1/DTD/xhtml1-transitionaldtd"> <html xmlns="http://wwww3org/1999/xhtml"> <head runat="server"> <title>Birthday Note</title> </head> <body> <form id="form1" runat="server"> <div> <asp:Calendar ID="Calendar1" runat="server" BackColor="White" BorderColor="Black" DayNameFormat="Shortest" Font-Names="Verdana" Font-Size="10pt" ForeColor="Black" Height="220px" NextPrevFormat="FullMonth"

It is straightforward developan M-file to implementNewtoninterpolation in Fig157, to As the first step is to compute the finite divided differencesand storethem in an array difThe ferences then usedin conjunctionwith Eq (1518)to per-form interpolation are the An exampleof a session using the function would be to duplicatethe calculation we just performed Exarnple153: in

sibly due to disuse atrophy), but some enlarge, resulting in a wider than normal range of ber size Groups of bers all at the same stage of atrophy undoubtedly relate to loss of motor innervation The reduction in conduction velocity and decrease in amplitude of motor nerve potentials and, to a greater extent, of sensory nerves in the aged may be taken as other indices of loss of motor and sensory axons All these changes are more marked in the legs than elsewhere However, when Roos and colleagues examined the contractile speed and ring rates of the quadriceps muscle in young men and compared them to those of men close to 80 years old, they found little difference despite a 50 percent reduction in the maximum voluntary contraction force developed by the muscle in the older men It has been repeatedly observed that age is an important prognostic factor in a large number of human diseases This effect is very evident, for example, in the markedly slower and less complete recovery from Guillain-Barre polyneuropathy in older age groups compared with younger ones One presumes that the structural changes of aging in peripheral nerves limit the degree of myelin regeneration and lower the threshold for failure of electrical transmission

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Gerontology is de ned as the study of aging and gerontologic neurology as the study of the effects of aging both of aging itself and of the age-related diseases on the nervous system In comparison to pediatric neurology, these disciplines have not aroused much interest The young physician is more excited by acute disease than by the seemingly immutable changes due to aging and is inclined to question whether medicine has a signi cant role to play

= Newtint(x,y,xx) function yint polynomial I'Jewton interpolal-ing % Newtint: = llewtrnt(x,y,xx): Uses an (n - 1)-order Newton yint ,x, yl polynrmial inr erpofdtrng "o bosed or n dala poinrs lyrnt) % to determine a vafue of the dependent variable at a given value of the independenc variable, xx % % input: :-lanor F va ' ' rh'c 1Fr x%

TitleFormat="Month" Width="800px" OnDayRender="CheckAppts"> <SelectedDayStyle BackColor="#CC3333" ForeColor="White" /> <SelectorStyle BackColor="#CCCCCC" Font-Bold="True" Font-Names="Verdana" Font-Size="8pt" ForeColor="#333333" Width="1%" /> <TodayDayStyle BackColor="#CCCC99" /> <OtherMonthDayStyle ForeColor="#999999" /> <DayStyle Width="14%" /> <NextPrevStyle Font-Size="8pt" ForeColor="White" /> <DayHeaderStyle BackColor="#CCCCCC" Font-Bold="True" Font-Size="7pt" ForeColor="#333333" Height="10pt" /> <TitleStyle BackColor="Black" Font-Bold="True" Font-Size="13pt" ForeColor="White" Height="14pt" /> </asp:Calendar> </div> </form> </body> </html>

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